In this final season, Dr. Helen Magnus and the Sanctuary team find that their previous allies have all turned against them. Now, in order to protect all beings, and to save their own lives, they must make their own rules.

Dr. Helen Magnus seeks out mysterious creatures to study and protect.

A doctor creates a safe haven which serves to protect creatures that most people consider to be monsters.

Decades-old found footage from NASA's abandoned Apollo 18 mission, where two American astronauts were sent on a secret expedition, reveals the reason the U.S. has never returned to the moon

The planet suffered an environmental collapse. The air became dangerous to breathe, the water became toxic, and billions of people died. Generations later humankind has finally re-established a rudimentary society, in which bounty hunters roam the land in search of wanted eco-criminals. Bounty hunter Attica Gage has a chance at the bounty of a lifetime: bringing down the ruthless outlaw, Thomas Jackson.

After a plane crash, Claire, a young therapist, is assigned by her mentor to counsel the flight's five survivors. They share their recollections of the incident. Some say there was an explosion, but the airline claims it never happened. Claire becomes intrigued by Eric, the most secretive of the passengers. Despite her better judgment, Claire's professional relationship with Eric blossoms into a romance. Then the survivors begin to disappear mysteriously,...